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. 2015 Feb;185(2):472–484. doi: 10.1016/j.ajpath.2014.10.007

Figure 6.

Figure 6

Critical role for forskolin in limiting UPEC invasion of RTECs. A: Effect of forskolin on bacterial binding to RTECs. B: Effect of forskolin on intracellular population of E. coli in RTECs. C: Effect of forskolin on bacterial exocytosis by RTECs. D: Effect of forskolin on intracellular cAMP in RTECs. E: Effect of H89 on intracellular population of E. coli in RTECs. F: Effect of H89 on bacterial exocytosis by RTECs. Data are expressed as means ± SEM. n = 4 (A–D). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, Student's t-test. CFU, colony-forming unit; Fsk, forskolin; RTEC, renal tubular epithelial cell; UPEC, uropathogenic Escherichia coli.