Table IV.

Results of Riley method and the Pseudo restricted maximum likelihood (Pseudo-REML) method applied to the three meta-analyses.

		Complete data scenario				Missing data scenario
Study	Method	Pooled estimates	95% CI	p-value		Pooled estimates	95% CI	p-value
Sasse †	Riley method	0.312	(0.104, 0.519)	0.003		—	—	—
	Pseudo-REML	0.320	(0.054, 0.585)	0.018		—	—	—
Zhao 2012‡	Riley method	−0.078	(−0.387, 0.232)	0.623		−0.281	(−0.688, 0.126)	0.176
	Pseudo-REML	−0.075	(−0.377, 0.228)	0.627		−0.300	(−0.928, 0.328)	0.349
Thompson 2005*	Riley method	0.055	(−0.050, 0.160)	0.304		0.072	(0.024, 0.121)	0.004
	Pseudo-REML	0.076	(−0.030, 0.181)	0.159		0.070	(0.030, 0.110)	0.001

^†The pooled estimate is the difference between the log-hazard ratio with respect to the overall survival and disease-free survival.

^‡The pooled estimate is the difference between the standard mean difference comparing cases and controls of paraoxonase activity and that of arylesterase activity.

^*The pooled estimate is logOR_{TT vs CC}/δP, which is the effect of one unit change in homocysteine level on logOR_{TT vs CC}.