Table 1.
Study Participants' Clinical and Imaging Characteristics
| Characteristic | Controls, n = 18 |
MAPT, n = 8 |
C9ORF72, n = 4 |
Sporadic, n = 11 |
All bvFTD, n = 23 |
pa | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| Age at baseline, yr | 61.3 | 9.5 | 56.7 | 8.9 | 64.1 | 8.7 | 68.8 | 8.4 | 63.8 | 10.0 | 0.4 |
| Disease duration at baseline, yr | 5.2 | 5.4 | 9.3 | 5.9 | 6.8 | 4.7 | 6.7 | 5.1 | N/A | ||
| Sex, M/F, No. | 12/6 | 5/3 | 4/0 | 10/1 | 18/5 | 0.7b | |||||
| Interscan interval, yr | 1.4 | 0.5 | 1.3 | 0.5 | 1.0 | 0.1 | 1.2 | 0.5 | 1.2 | 0.4 | 0.2 |
| Education, yr | 16.55 | 1.42 | 14.6 | 3.9 | 15.5 | 4.1 | 16.6 | 3.0 | 15.5 | 3.5 | 0.3 |
| MMSE baseline | 29.7 | 0.6 | 25.5 | 4.2 | 2.5 | 6.9 | 25.8 | 3.4 | 25.3 | 4.2 | <0.001c |
| MMSE follow-up | 29.7 | 0.5 | 26.3 | 5.4 | 25.3 | 4.3 | 25.1 | 3.5 | 25.6 | 4.2 | 0.002c |
| TIV, ml | 1,572 | 134 | 1,503 | 135 | 1,649 | 135 | 1,565 | 123 | 1,556 | 137 | 0.6 |
| Whole brain volume, baseline, ml | 1,193 | 91 | 1,047 | 88 | 1,192 | 93 | 1,026 | 48 | 1,070 | 95 | 0.001 |
| Whole brain volume, follow-up, ml | 1,184 | 95 | 1,028 | 95 | 1,167 | 93 | 1,001 | 37 | 1,047 | 95 | <0.001 |
| BBSI, ml/yr | 5.2 | 6.7 | 15.7 | 6.7 | 14.4 | 17.8 | 14.8 | 10.6 | 15.2 | 10.4 | 0.002 |
a
Linear regression comparing controls with all bvFTD subjects.
b
Fisher exact test.
c
Wilcoxon rank sum test.
BBSI = brain boundary shift integral; bvFTD = behavioral variant frontotemporal dementia; C9ORF72 = chromosome 9 open-reading frame 72; F = female; M = male; MAPT = microtubule-associated protein tau; MMSE = Mini-Mental State Examination; SD = standard deviation; TIV = total intracranial volume.