Table 3.

Baseline Diffusion Tensor Imaging Metric Data for Individual White Matter Regions of Interest for Control Participants and Patients

Regions of Interest	Controls, n = 18		bvFTD, n = 19		% Difference	95% Confidence Interval		pa
	Mean	SD	Mean	SD
FA
Genu corpus callosum	0.74	0.03	0.73	0.04	0.34	−2.64	3.31	0.8
Body corpus callosum	0.70	0.04	0.66	0.04	−4.87	−8.68	−1.07	0.01
Splenium corpus callosum	0.79	0.02	0.78	0.02	−1.27	−3.15	0.61	0.2
Cingulum (paracallosal) R	0.63	0.05	0.58	0.06	−4.26	−9.25	0.73	0.09
Cingulum (paracallosal) L	0.60	0.04	0.55	0.07	−2.25	−7.08	2.59	0.4
Cingulum (parahippocampal) R	0.43	0.04	0.38	0.04	−5.77	−9.59	−1.96	0.004
Cingulum (parahippocampal) L	0.45	0.04	0.40	0.04	−5.26	−9.19	−1.33	0.01
Fornix	0.59	0.03	0.57	0.04	−1.91	−4.21	0.40	0.1
Uncinate fasciculus R	0.48	0.05	0.43	0.04	−4.65	−8.62	−0.67	0.02
Uncinate fasciculus L	0.48	0.04	0.43	0.07	−6.24	−11.32	−1.16	0.02
Corticospinal tract R	0.62	0.05	0.62	0.07	−1.45	−7.15	4.25	0.6
Corticospinal tract L	0.65	0.04	0.64	0.05	−2.15	−6.12	1.81	0.3
SCP R	0.79	0.05	0.78	0.06	−2.24	−7.21	2.72	0.4
SCP L	0.79	0.04	0.77	0.05	−2.88	−7.19	1.42	0.2
MD, 10−3mm2/s
Genu corpus callosum	0.76	0.04	0.80	0.08	0.29	−4.81	5.40	0.9
Body corpus callosum	0.80	0.06	0.88	0.08	8.66	2.55	14.76	0.01
Splenium corpus callosum	0.74	0.03	0.77	0.05	3.80	−0.12	7.72	0.06
Cingulum (paracallosal) R	0.72	0.04	0.72	0.05	1.64	−2.48	5.76	0.4
Cingulum (paracallosal) L	0.71	0.04	0.73	0.05	0.47	−3.49	4.43	0.8
Cingulum (parahippocampal) R	0.74	0.03	0.85	0.12	9.32	1.49	17.15	0.02
Cingulum (parahippocampal) L	0.73	0.04	0.83	0.11	10.63	3.09	18.17	0.007
Fornix	0.84	0.06	0.91	0.10	5.44	−0.09	10.97	0.05
Uncinate fasciculus R	0.70	0.04	0.83	0.13	13.50	4.81	22.19	0.003
Uncinate fasciculus L	0.71	0.03	0.85	0.18	14.87	2.65	27.10	0.02
Corticospinal tract R	0.66	0.06	0.67	0.09	1.84	−5.28	8.96	0.6
Corticospinal tract L	0.62	0.05	0.62	0.09	2.45	−4.32	9.22	0.5
SCP R	0.85	0.07	0.87	0.09	5.41	−1.96	12.78	0.1
SCP L	0.78	0.07	0.80	0.07	4.22	−2.29	10.72	0.2

^aLinear regression comparing bvFTD with controls after adjusting for age, gender, and disease duration.

vFTD = behavioral variant frontotemporal dementia; FA = fractional anisotropy; L = left; MD = mean diffusivity; R = right; SCP = superior cerebellar peduncle; SD = standard deviation.