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. 2014 Nov 19;18(6):508. doi: 10.1186/s13054-014-0508-y

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© Wu et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Details of the study design. Healthy volunteers and patients with stable chronic obstructive pulmonary disease (sCOPD) or acute exacerbation of COPD (AECOPD) at day 1 (D1), day 3 (D3) or day 10 (D10) of hospital admission of hospital were recruited into the present study according to the criteria stated in the text. All clinical information was collected and transferred into the clinical informatics database using the Digital Evaluation Score System. mRNAs of peripheral blood monocytes were harvested, and gene expression profiles were measured by human gene expression array and subjected to bioinformatics analysis. AECOPD-specific biomarkers were selected by integrating gene functional networks and profiles with clinical informatics data.