Table 11.
Number of downregulated genes in peripheral blood mononuclear cells of healthy control subjects, patients with stable COPD and patients with AECOPD a
| Fold changes in upregulated genes ( n ) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Compared pairs | >2 | >5 | >6 | >8 | >10 | >15 | >20 | >30 | >50 | >100 |
| Stable vs Con | 4,516 | 135 | 55 | 9 | 4 | 2 | 1 | 0 | 0 | 0 |
| AE-1 vs Con | 2,975 | 182 | 107 | 47 | 22 | 7 | 4 | 1 | 0 | 0 |
| AE-3 vs Con | 3,426 | 225 | 149 | 65 | 35 | 11 | 5 | 2 | 0 | 0 |
| AE-10 vs Con | 2,798 | 124 | 73 | 31 | 16 | 2 | 1 | 1 | 0 | 0 |
| AE-1 vs Stable | 3,207 | 33 | 16 | 4 | 4 | 2 | 0 | 0 | 0 | 0 |
| AE-3 vs Stable | 4,510 | 125 | 71 | 21 | 8 | 3 | 1 | 0 | 0 | 0 |
| AE-10 vs Stable | 5,288 | 445 | 236 | 97 | 49 | 20 | 8 | 3 | 0 | 0 |
| AE-3 vs AE-1 | 598 | 32 | 23 | 17 | 5 | 3 | 2 | 0 | 0 | 0 |
| AE-10 vs AE-1 | 2,162 | 261 | 168 | 82 | 43 | 21 | 14 | 10 | 5 | 1 |
| AE-10 vs AE-3 | 1,918 | 192 | 130 | 66 | 36 | 15 | 9 | 6 | 4 | 0 |
aData are from controls (Con) or patients with stable chronic obstructive pulmonary disease (Stable) or acute exacerbation of chronic obstructive pulmonary disease on day 1 (AE-1), day 3 (AE-3) and day 10 (AE-10) of the hospital admission.