Table 12.
Genes downregulated more than tenfold in peripheral blood mononuclear cells of patients with stable COPD or AECOPD compared to healthy control subjects a
| Stable vs Con | AE-1 vs Con | AE-3 vs Con | AE-10 vs Con | ||||
|---|---|---|---|---|---|---|---|
| Fold changes | Genes | Fold changes | Genes | Fold changes | Genes | Fold changes | Genes |
| 10.7 | EIF3S6 | 10.3 | HAND1 | 10.2 | GZMK | 10.0 | C21orf7 |
| 10.7 | YLPM1 | 10.3 | CD8B | 10.5 | CXCR3 | 10.0 | NELL2 |
| 16.1 | TFCP2L1 | 10.4 | UBASH3A | 10.6 | AK5 | 10.4 | C21orf7 |
| 21.0 | SCP2 | 10.8 | TRA@ | 10.7 | TRA@ | 10.4 | GFI1B |
| 10.9 | TRBV3-1 | 10.7 | IL24 | 10.5 | LOC129293 | ||
| 11.2 | CD8B | 10.9 | CD6 | 10.5 | LOC123876 | ||
| 11.4 | MAL | 10.9 | N/A | 10.7 | HIST1H3H | ||
| 11.4 | LOC643514 | 11.2 | KIAA0748 | 11.1 | IL24 | ||
| 11.5 | NELL2 | 11.4 | LCK | 11.4 | GFI1B | ||
| 11.7 | TTC24 | 11.5 | CD8B | 11.9 | CRTAC1 | ||
| 12.7 | CD8B | 12.3 | APBB1 | 11.9 | OR10A4 | ||
| 13.1 | LEF1 | 12.3 | IL12RB1 | 11.9 | SAA3P | ||
| 13.8 | TCF7 | 12.5 | TTC24 | 12.7 | TTC24 | ||
| 14.2 | LOC129293 | 12.5 | GFI1B | 14.9 | TFCP2L1 | ||
| 14.5 | LOC129293 | 12.5 | CRTAC1 | 18.6 | SCP2 | ||
| 15.6 | TCF7 | 12.6 | TRBV3-1 | 32.3 | UNQ470 | ||
| 16.1 | TCF7 | 12.6 | ATG9B | ||||
| 16.8 | CD8B | 12.9 | ABLIM1 | ||||
| 21.8 | TFCP2L1 | 12.9 | LOC129293 | ||||
| 25.4 | CRTAC1 | 13.0 | CD8B | ||||
| 27.9 | SCP2 | 13.1 | CD28 | ||||
| 44.1 | UNQ470 | 13.1 | GRAP2 | ||||
| 14.3 | UBASH3A | ||||||
| 14.4 | CCR7 | ||||||
| 15.0 | LOC129293 | ||||||
| 16.0 | CD8B | ||||||
| 18.1 | UNQ470 | ||||||
| 18.7 | SCP2 | ||||||
| 18.8 | LEF1 | ||||||
| 19.3 | LEF1 | ||||||
| 23.5 | CD8B | ||||||
| 24.3 | TCF7 | ||||||
| 25.1 | TCF7 | ||||||
| 30.4 | TCF7 | ||||||
| 32.0 | TFCP2L1 | ||||||
aData are from patients with stable chronic obstructive pulmonary disease (Stable) or acute exacerbation of chronic obstructive pulmonary disease on day 1 (AE-1), day 3 (AE-3) and day 10 (AE-10) of the hospital admission, as compared to healthy controls (Con).