Table 19.
Number of genes in peripheral blood mononuclear cells of patients with AECOPD a
| Down–down | Down–up | Up–down | Up–up | ||
|---|---|---|---|---|---|
| Total | 353 | 784 | 1,005 | 127 | |
| >2-fold | 52 | 131 | 238 | 8 | |
| >4-fold | 3 | 3 | 7 | 0 | |
| >5-fold | 2 | 0 | 0 | 0 | |
| Selected co–differentially expressed genes at the down–down pattern (>4-fold) | |||||
| SEQ-ID | Gene name | Full name of gene | AE-3 vs AE-1 | AE-10 vs AE-3 | |
| NM_000032 | ALAS2 | Aminolevulinate, delta-, synthase 2 | 6.4 | 6.5 | |
| BC099627 | EPB42 | Erythrocyte membrane protein band 4.2 | 9.9 | 4.4 | |
| BC027890 | CA1 | Carbonic anhydrase I | 21.6 | 5.1 | |
| Selected co–differentially expressed genes at the down–up pattern (>4-fold) | |||||
| SEQ-ID | Gene name | Full name of gene | AE-3 vs AE-1 | AE-10 vs AE-3 | |
| AK127453 | N/A | Homo sapiens cDNA FLJ45545 fis, clone BRTHA2034281. | 4.7 | 5.7 | |
| NM_003944 | SELENBP1 | Selenium-binding protein 1 | 5.6 | 4.1 | |
| BC090921 | MYH9 | Myosin, heavy chain 9, non-muscle | 6.2 | 4.1 | |
| Selected co–differentially expressed genes at the up–down pattern (>4-fold) | |||||
| SEQ-ID | Gene name | Full name of gene | AE-3 vs AE-1 | AE-10 vs AE-3 | |
| NM_181717 | HCG27 | HLA complex group 27 | 4.1 | 7.3 | |
| NM_177551 | GPR109A | G protein-coupled receptor 109A | 4.3 | 7.5 | |
| NM_006018 | GPR109B | G protein-coupled receptor 109B | 4.4 | 5.1 | |
| AF249277 | MTHFS | 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) | 4.6 | 5.3 | |
| AY234180 | BCL2A1 | BCL2-related protein A1 | 5.2 | 4.0 | |
| BC010952 | PI3 | Peptidase inhibitor 3, skin-derived (SKALP) | 6.0 | 4.4 | |
| NM_002243 | KCNJ15 | Potassium inwardly rectifying channel, subfamily J, member 15 | 7.0 | 4.8 | |
| Selected co–differentially expressed genes at the up–up pattern (>2-fold) | |||||
| SEQ-ID | Gene name | Full name of gene | AE-3 vs AE-1 | AE-10 vs AE-3 | |
| Z15108 | PRKCZ | Protein kinase C, zeta | 2.0 | 2.8 | |
| BC037798 | CGI-38 | Brain-specific protein | 2.0 | 2.4 | |
| NM_001033581 | PRKCZ | Protein kinase C, zeta | 2.1 | 2.8 | |
| NM_007168 | ABCA8 | ATP-binding cassette, subfamily A, member 8 | 2.1 | 4.0 | |
| AK022468 | SORBS1 | Sorbin and SH3 domain containing 1 | 2.3 | 3.5 | |
| NM_006403 | NEDD9 | Neural precursor cell expressed, developmentally downregulated 9 | 2.3 | 2.2 | |
| NM_023037 | FRY | Furry homologue (Drosophila) | 2.3 | 2.1 | |
| NM_016730 | FOLR1 | Folate receptor 1 (adult) | 3.0 | 11.7 | |
| Down–down | GENE_NAME | SEQ_ID | AE-1 vs Stable | AE-3 vs Stable | AE-10 vs Stable |
| ALAS2 | NM_000032 | 17.64 | 2.76 | −2.37 | |
| EPB42 | BC099627 | 10.02 | 1.01 | −4.37 | |
| CA1 | BC027890 | 103.93 | 4.81 | −1.06 | |
| Down–up | GENE_NAME | SEQ_ID | AE-1 vs Stable | AE-3 vs Stable | AE-10 vs Stable |
| N/A | AK127453 | −1.69 | −7.90 | −1.38 | |
| SELENBP1 | NM_003944 | 3.97 | −1.41 | 2.92 | |
| MYH9 | BC090921 | −1.36 | −8.40 | −2.04 | |
| Up–down | GENE_NAME | SEQ_ID | AE-1 vs Stable | AE-3 vs Stable | AE-10 vs Stable |
| HCG27 | NM_181717 | 1.09 | 4.47 | −1.63 | |
| GPR109A | NM_177551 | 4.12 | 17.79 | 2.36 | |
| GPR109B | NM_006018 | 2.64 | 11.64 | 2.28 | |
| MTHFS | AF249277 | 4.51 | 20.75 | 3.95 | |
| BCL2A1 | AY234180 | 2.38 | 12.45 | 3.11 | |
| PI3 | BC010952 | 1.03 | 6.20 | 1.42 | |
| KCNJ15 | NM_002243 | 2.25 | 15.78 | 3.26 | |
| Up–up | GENE_NAME | SEQ_ID | AE-1 vs Stable | AE-3 vs Stable | AE-10 vs Stable |
| PRKCZ | Z15108 | −1.25 | 1.61 | 4.46 | |
| CGI-38 | BC037798 | −5.87 | −2.86 | −1.18 | |
| PRKCZ | NM_001033581 | −1.61 | 1.30 | 3.64 | |
| ABCA8 | NM_007168 | −1.27 | 1.68 | 6.69 | |
| SORBS1 | AK022468 | 1.28 | 2.92 | 10.30 | |
| NEDD9 | NM_006403 | 2.43 | 5.57 | 12.15 | |
| FRY | NM_023037 | −1.11 | 2.08 | 4.34 | |
| FOLR1 | NM_016730 | −4.20 | −1.39 | 8.39 | |
aData are from acute exacerbation of chronic obstructive pulmonary disease on day 1 (AE-1), day 3 (AE-3) and day 10 (AE-10) of the hospital admission. Comparisons are between AE-1 and AE-3 or between AE-3 and AE-10.