Table 5.
Genes upregulated between 20- and 30-fold in peripheral blood mononuclear cells of patients with stable COPD or AECOPD compared with healthy control subjects a
| Stable vs control | AE-1 vs control | AE-3 vs control | AE-10 vs control | ||||
|---|---|---|---|---|---|---|---|
| Fold changes | Genes | Fold changes | Gene | Fold changes | Genes | Fold changes | Genes |
| 20.1 | P8 | 20.3 | PLAU | 20.0 | ALPL | 20.3 | SCNN1A |
| 20.1 | REXO1L5P | 21.0 | COL6A3 | 20.1 | MUC1 | 20.4 | MGC45438 |
| 20.2 | UNQ473 | 21.1 | SLC25A37 | 20.2 | SPDEF | 20.7 | FBLN1 |
| 20.2 | DEFA1 | 21.1 | HIG2 | 20.3 | HIG2 | 20.7 | CLDN4 |
| 20.5 | LOC440015 | 21.2 | GPRC5A | 20.4 | KLK11 | 20.9 | SFTPA2 |
| 21.1 | LOC391749 | 21.2 | CFB | 20.4 | MGP | 21.0 | FKBP9 |
| 21.3 | MGC45438 | 21.3 | LTF | 20.4 | GPR109A | 21.1 | FAM107A |
| 21.7 | RP11-146D12.2 | 21.4 | VSIG4 | 21.0 | LOC653342 | 21.3 | N/A |
| 22.0 | LOC399839 | 21.7 | FOSB | 21.1 | CFB | 21.4 | C10orf10 |
| 22.9 | SPDEF | 21.9 | SLC25A37 | 21.3 | P8 | 21.5 | SELENBP1 |
| 23.0 | CLDN4 | 22.0 | ARG1 | 21.8 | PBEF1 | 21.6 | ANXA3 |
| 24.7 | LOC349196 | 22.0 | SPDEF | 21.9 | S100P | 21.6 | IFI27 |
| 25.3 | STAC2 | 22.2 | LTF | 21.9 | MS4A3 | 21.8 | C1QC |
| 25.8 | REXO1L3P | 22.3 | FOS | 22.4 | COL6A3 | 21.9 | SEPP1 |
| 26.3 | SCGB3A1 | 22.6 | FAM46C | 23.1 | MANSC1 | 22.0 | KLK11 |
| 26.9 | RNASE1 | 22.6 | ISLR | 23.2 | COL1A2 | 22.1 | P8 |
| 27.0 | AZGP1 | 22.6 | COL1A2 | 23.2 | GCA | 22.1 | LOC653723 |
| 29.5 | H19 | 22.8 | ATP1B1 | 23.3 | LTBP2 | 22.5 | LOC391359 |
| 23.8 | SCNN1A | 23.9 | CHI3L1 | 22.7 | LAMB2 | ||
| 23.8 | SERPINE1 | 24.0 | TMC5 | 22.8 | AQP1 | ||
| 23.8 | EPB42 | 24.2 | CD24 | 24.0 | C9orf61 | ||
| 23.8 | C1QC | 24.2 | HP | 24.1 | C4BPA | ||
| 23.9 | RGS1 | 24.3 | ISLR | 24.2 | LTBP2 | ||
| 23.9 | ORM2 | 24.3 | SIX1 | 24.3 | UNQ473 | ||
| 24.1 | COL5A1 | 24.5 | APOE | 24.5 | TMEM139 | ||
| 24.5 | MS4A3 | 24.6 | COL3A1 | 24.6 | N/A | ||
| 25.6 | CD177 | 24.6 | LOC646309 | 25.7 | OLFML3 | ||
| 25.6 | APOE | 24.7 | CEACAM3 | 25.9 | SNF1LK | ||
| 26.4 | C20orf114 | 24.9 | AATK | 25.9 | A2M | ||
| 26.6 | BPIL1 | 25.3 | LTF | 26.4 | FXYD3 | ||
| 27.1 | CTSG | 25.4 | ALPL | 27.0 | HP | ||
| 27.4 | FOS | 25.6 | ACSL1 | 27.1 | N/A | ||
| 27.6 | ALAS2 | 26.2 | CEACAM6 | 27.4 | LOC653509 | ||
| 28.0 | INHBA | 26.3 | COL5A1 | 28.0 | LDB2 | ||
| 28.0 | TIMP3 | 26.4 | KLK11 | 28.0 | OLFML3 | ||
| 28.1 | COL3A1 | 26.7 | PRTN3 | 28.5 | SFTPA1 | ||
| 28.1 | SLC4A1 | 26.9 | RGS1 | 28.6 | MUC1 | ||
| 28.2 | KLK11 | 27.3 | KCNJ15 | 29.6 | HSPA12B | ||
| 28.2 | LOC653492 | 27.4 | CAMP | 29.8 | MFAP4 | ||
| 28.5 | LOC203510 | 27.6 | PLAU | ||||
| 28.7 | CEACAM3 | 27.8 | LTF | ||||
| 28.8 | DCN | 27.9 | ANXA3 | ||||
| 28.9 | CEACAM1 | 28.0 | H19 | ||||
| 29.0 | CEACAM6 | 28.0 | SERPINE1 | ||||
| 29.3 | SELENBP1 | 28.1 | LTF | ||||
| 29.7 | KRT19 | 28.3 | INHBA | ||||
aData are from patients with stable chronic obstructive pulmonary disease (Stable) or acute exacerbation of chronic obstructive pulmonary disease on day 1 (AE-1), day 3 (AE-3) and day 10 (AE-10) of hospital admission, as compared to healthy controls.