Table 6.
Genes upregulated between 15- and 20-fold in peripheral blood mononuclear cells of patients with stable COPD or AECOPD compared with healthy control subjects a
| Stable vs control | AE-1 vs control | AE-3 vs control | AE-10 vs control | ||||
|---|---|---|---|---|---|---|---|
| Fold changes | Genes | Fold changes | Genes | Fold changes | Genes | Fold changes | Genes |
| 15.2 | LOC645558 | 15.0 | CNN3 | 15.0 | GPR109B | 15.0 | USP54 |
| 15.7 | N/A | 15.0 | GPT2 | 15.0 | LOC653492 | 15.0 | MGC45438 |
| 15.9 | LOC653455 | 15.1 | ORM1 | 15.2 | RNASE1 | 15.2 | SLCO2A1 |
| 15.9 | DUX4 | 15.1 | LOC402110 | 15.3 | FN1 | 15.3 | AGER |
| 16.1 | LOC653768 | 15.1 | MDK | 15.5 | ACSL1 | 15.3 | FLJ11259 |
| 16.5 | RAB17 | 15.2 | ELF3 | 15.5 | CDH5 | 15.5 | CLEC3B |
| 16.6 | LOC653541 | 15.2 | PSG8 | 15.6 | FOLR3 | 15.8 | ADCY4 |
| 16.6 | LOC391763 | 15.3 | SLC25A37 | 15.8 | PVRL2 | 16.0 | FN1 |
| 16.7 | LOC642286 | 15.4 | FKBP9 | 15.9 | KRT19 | 16.1 | HP |
| 16.7 | S100A14 | 15.5 | C1QB | 15.9 | MDK | 16.1 | CKB |
| 16.7 | NBPF9 | 15.6 | BPGM | 16.0 | APOC1 | 16.1 | CYP4B1 |
| 16.9 | PSG8 | 15.7 | AQP9 | 16.3 | NOL3 | 16.2 | RARRES2 |
| 17.0 | REXO1L6P | 15.7 | LOC402207 | 16.3 | ATP1B1 | 16.3 | TSPAN1 |
| 17.0 | MLPH | 15.7 | PSG11 | 16.4 | TMC4 | 16.6 | SDC4 |
| 17.1 | FAM90A7 | 16.0 | KLK11 | 16.4 | VEGF | 16.7 | ERG |
| 17.4 | LOC401650 | 16.2 | KIAA0703 | 16.6 | SPAG4 | 16.8 | LOC653107 |
| 17.8 | DUB3 | 16.2 | IGFBP5 | 16.8 | LIF | 17.2 | RAB25 |
| 17.9 | MGC45438 | 16.2 | IGFBP3 | 16.8 | CCDC80 | 17.2 | COL1A2 |
| 18.9 | COL3A1 | 16.2 | N/A | 16.9 | CEACAM3 | 17.3 | DCN |
| 19.1 | LOC645732 | 16.2 | SLC25A37 | 16.9 | IGFBP3 | 17.5 | TSPAN13 |
| 19.8 | LOC392188 | 16.3 | SIX1 | 17.1 | CXCL2 | 17.6 | HSD17B6 |
| 20.0 | MUC1 | 16.3 | LOC645009 | 17.2 | FKBP9 | 17.8 | RHOB |
| 16.4 | C1QA | 17.2 | CEACAM1 | 17.9 | KRT19 | ||
| 16.5 | UBD | 17.7 | ELF3 | 18.0 | AQP9 | ||
| 16.6 | LOC653342 | 17.7 | CNN3 | 18.2 | FOLR1 | ||
| 17.0 | GPR97 | 17.8 | PGLYRP1 | 18.2 | IL1RL1 | ||
| 17.1 | COL1A1 | 17.9 | KRT23 | 18.2 | SERPING1 | ||
| 17.3 | ALPL | 18.1 | SLC44A4 | 18.3 | MGC35295 | ||
| 17.4 | FBLN1 | 18.1 | SCNN1A | 18.4 | FLJ43663 | ||
| 17.5 | HIG2 | 18.4 | FBLN1 | 18.6 | TGM2 | ||
| 17.7 | COL8A1 | 18.5 | HPR | 18.6 | ADH1C | ||
| 17.9 | TMC5 | 18.6 | SYT7 | 18.7 | KIAA1026 | ||
| 18.1 | LTBP2 | 18.6 | CEACAM8 | 19.1 | DKFZP686A01247 | ||
| 18.4 | SLC25A37 | 18.8 | C1R | 19.2 | CCDC48 | ||
| 18.7 | CEACAM3 | 18.8 | COL1A1 | 19.2 | ANKRD25 | ||
| 18.9 | MPO | 18.9 | COL8A1 | 19.3 | DMBT1 | ||
| 19.0 | CD24 | 18.9 | C1QC | 19.4 | MALL | ||
| 19.0 | CHI3L1 | 18.9 | SFRP2 | 19.5 | ANXA8 | ||
| 19.0 | DCN | 19.0 | HIG2 | 19.5 | SPRY4 | ||
| 19.1 | P8 | 19.2 | C1QB | 19.7 | ELF3 | ||
| 19.1 | CEACAM6 | 19.2 | GPRC5A | 19.9 | EHD2 | ||
| 19.1 | ACSL1 | 19.3 | MMP25 | 20.0 | DCN | ||
| 19.5 | PRTN3 | 19.3 | UBD | ||||
| 19.5 | LIF | 19.3 | GADD45A | ||||
| 19.6 | LTF | 19.4 | ISLR | ||||
| 19.7 | ANXA3 | 19.5 | ORM1 | ||||
| 19.7 | C1R | 19.5 | C20orf114 | ||||
| 19.7 | MUC1 | 19.5 | LOC203510 | ||||
| 19.8 | PSG4 | 19.6 | DCN | ||||
| 19.9 | HP | 19.7 | FN1 | ||||
| 19.8 | DAAM2 | ||||||
| 19.9 | FOLR3 | ||||||
aData are from patients with stable chronic obstructive pulmonary disease (Stable) or acute exacerbation of chronic obstructive pulmonary disease on day 1 (AE-1), day 3 (AE-3) and day 10 (AE-10) of hospital admission, as compared to healthy controls.