Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec 20;16:505. doi: 10.1186/s13058-014-0505-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Sendon-Lago et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Deletion analysis identified a Pit-1-responsive region in the human MMP-1 and MMP-13 promoter. (A) The MMP-1 promoter fragments that fused to the pGL2-Basic vector (pGL2B) were transfected into MCF-7 cells and then transfected with the pRc/RSV or the pRSV-hPit-1 vector. Normalized relative luciferase units (RLU) were calculated as the ratio of luciferase activity in the pRSV-hPit-1-transfected cells to that in the corresponding control (pRc/RSV-transfected) cells. (B) The MMP-13 promoter fragments that fused to the pGL2Basic vector (pGL2B) were transfected as indicated in A. Data are expressed as indicated in A. MMP-1, matrix metalloproteinase-1; MMP-13, matrix metalloproteinase-13; Pit-1, POU class 1 homeobox 1.