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. 2014 Dec 20;16:505. doi: 10.1186/s13058-014-0505-8

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© Sendon-Lago et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Pit-1 expression in human ductal invasive carcinomas of the breast positively correlates with MMP-1 and MMP-13 expression. (A) Representative set of negative and positive (1+, 2+, and 3+) Pit-1, MMP-1, and MMP-13 immunodetection in human breast invasive ductal carcinomas. Scale bar: 100 μm. (B) Representative figures of positive Pit-1, MMP-1, and MMP-13 expression in tumor cells (1), fibroblasts (2), and mononuclear inflammatory cells (MIC, 3). (C) Plots of median score values of MMP-1 and MMP-13 as a function of Pit-1 score groups, and table with the values of Spearman correlation test. n = 110 human breast tumors. MMP-1, matrix metalloproteinase-1; MMP-13, matrix metalloproteinase-13; Pit-1, POU class 1 homeobox 1.