Table 1.
Distribution of Clinical and Laboratory Data and Thrombocytopenia Status, by Clinical and Demographic Group
| Variable | Clinical Events, No. | Patients, No. | Distribution of Clinical and Laboratory Data |
Platelet Data |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OP Events, No. |
OP Events With Platelet Count, No. (%)a |
IP Events, No. | IP Events With Platelet Count, No. (%)a |
Mean Platelet Count (per 1000) |
P Valueb | < 50 000 Platelets/μL, No. (%) |
P Valueb | |||
| Infecting Plasmodium species | ||||||||||
| None (negative test results) | 753 595 | 135 229 | 695 051 | 105 432 (15.2) | 58 544 | 43 626 (74.5) | 256.37 ± 141.38 | Ref | 4084 (2.7) | Ref |
| P. falciparum | 89 748 | 44 171 | 73 392 | 21 828 (29.7) | 16 356 | 14 931 (91.3) | 129.03 ± 100.47 | <.001 | 5722 (15.6) | <.001 |
| P. vivax | 54 495 | 28 841 | 49 041 | 14 512 (29.6) | 5454 | 5040 (92.4) | 165.42 ± 121.37 | <.001 | 1650 (8.4) | <.001 |
| >1 (mixed infection) | 19 569 | 14 206 | 16 210 | 5411 (33.4) | 3359 | 3089 (92) | 128.98 ± 96.19 | <.001 | 1148 (13.5) | .203 |
| P. malariae | 4598 | 4045 | 4190 | 1198 (28.6) | 408 | 382 (93.6) | 142.66 ± 98.15 | <.001 | 116 (7.3) | <.001 |
| P. ovale | 115 | 110 | 105 | 22 (21) | 10 | 8 (80) | 146.2 ± 79.97 | <.001 | 2 (6.7) | <.001 |
| Sex | ||||||||||
| Female | 506 055 | 70 493 | 458 599 | 78 552 (17.1) | 47 456 | 38 562 (81.3) | 219.24 ± 136.35 | Ref | 6051 (5.2) | Ref |
| Male | 416 065 | 80 186 | 379 390 | 69 851 (18.4) | 36 675 | 28 514 (77.7) | 222.03 ± 149.37 | .008 | 6671 (6.8) | <.001 |
| Ethnic group | ||||||||||
| Non-Papuan | 149 017 | 44 196 | 136 604 | 22 851 (16.7) | 12 413 | 9146 (73.7) | 247.13 ± 123.31 | Ref | 822 (2.6) | Ref |
| Highland Papuan | 644 073 | 79 443 | 586 388 | 105 757 (18) | 57 685 | 47 318 (82) | 203.73 ± 137.81 | <.001 | 11 235 (7.3) | <.001 |
| Lowland Papuan | 127 385 | 26 413 | 113 440 | 19 589 (17.3) | 13 945 | 10 555 (75.7) | 277.5 ± 164.07 | <.001 | 654 (2.2) | .003 |
| Age, y | ||||||||||
| <1 | 70 221 | 20 086 | 55 359 | 12 998 (23.5) | 14 862 | 6595 (44.4) | 323.49 ± 177.22 | <.001 | 651 (3.3) | <.001 |
| 1 to <5 | 139 033 | 23 596 | 124 985 | 29 337 (23.5) | 14 048 | 11 230 (79.9) | 279.93 ± 170.61 | <.001 | 1403 (3.5) | <.001 |
| 5 to <15 | 107 163 | 23 318 | 100 319 | 19 341 (19.3) | 6844 | 6177 (90.3) | 214.15 ± 136.73 | <.001 | 1478 (5.8) | <.001 |
| ≥15 | 605 588 | 101 728 | 557 250 | 86 659 (15.6) | 48 338 | 43 046 (89.1) | 187.57 ± 111.13 | Ref | 9188 (7.1) | Ref |
| Malaria presentations in the past 2 mo, no. | ||||||||||
| 0 | 799 988 | 150 448 | 724 429 | 126 653 (17.5) | 75 559 | 59 237 (78.4) | 221.41 ± 142.98 | Ref | 11 268 (6.1) | Ref |
| ≥1 | 122 132 | 31 080 | 113 560 | 21 750 (19.2) | 8572 | 7839 (91.4) | 214.90 ± 138.89 | <.001 | 1454 (4.9) | <.001 |
| Year | ||||||||||
| 2004 | 62 985 | 25 864 | 56 227 | 8316 (14.8) | 6758 | 4495 (66.5) | 205.66 ± 149.48 | Ref | 1045 (8.2) | Ref |
| 2005 | 88 400 | 30 950 | 78 398 | 16 676 (21.3) | 10 002 | 8498 (85) | 219.91 ± 153.23 | <.001 | 1688 (6.7) | <.001 |
| 2006 | 96 086 | 34 260 | 86 288 | 12 667 (14.7) | 9798 | 8312 (84.8) | 243.51 ± 160.02 | <.001 | 1.025 (4.9) | <.001 |
| 2007 | 106 046 | 36 914 | 95 272 | 12 872 (13.5) | 10 774 | 8469 (78.6) | 220.4 ± 148.08 | <.001 | 1533 (7.2) | .002 |
| 2008 | 98 074 | 34 127 | 88 967 | 11 184 (12.6) | 9107 | 7504 (82.4) | 211.83 ± 134.54 | .001 | 1245 (6.7) | <.001 |
| 2009 | 110 796 | 34 341 | 100 756 | 20 165 (20) | 10 040 | 8188 (81.6) | 212.5 ± 133.49 | <.001 | 1716 (6.1) | <.001 |
| 2010 | 112 566 | 35 041 | 103 263 | 22 152 (21.5) | 9303 | 7525 (80.9) | 214.67 ± 136.52 | <.001 | 1735 (5.8) | <.001 |
| 2011 | 115 683 | 37 055 | 106 640 | 18 840 (17.7) | 9043 | 6654 (73.6) | 225.24 ± 133.65 | <.001 | 1230 (4.8) | <.001 |
| 2012 | 131 484 | 41 495 | 122 178 | 25 531 (20.9) | 9306 | 7431 (79.9) | 225.64 ± 136.95 | <.001 | 1505 (4.6) | <.001 |
| Overall | 922 120 | 150 448 | 837 989 | 148 403 (17.7) | 84 131 | 67 076 (79.7) | 220.52 ± 142.44 | 12 722 (5.9) | ||
Abbreviations: IP, inpatient; OP, outpatient; Ref, reference.
a
Events in which the platelet count was measured.
b
Based on univariable linear regression with correction of the variance-covariance matrix for within-patient correlation.