Table 4.
Risk of Mortality According to Severe Thrombocytopenia, Severe Anemia, and Malaria Status
| Variable | Platelet Count ≥50 000 Platelets/μL, Hb Level <5 g/dL |
Platelet Count <50 000 Platelets/µL, Hb Level ≥5 g/dL |
Platelet Count <50 000 Platelets/µL, Hb Level <5 g/dL |
|||
|---|---|---|---|---|---|---|
| Adjusted OR (95% CI)a | P Value | Adjusted OR (95% CI)a | P Value | Adjusted OR (95% CI)a | P Value | |
| Infecting Plasmodium speciesa | ||||||
| None (negative test results) | 5.10 (4.32–6.01) | <.001 | 6.21 (5.37–7.20) | <.001 | 17.14 (13.61–21.58) | <.001 |
| P. falciparum | 5.05 (3.64–7.00) | <.001 | 2.71 (2.06–3.55) | <.001 | 16.97 (11.81–24.38) | <.001 |
| P. vivax | 4.04 (2.22–7.33) | <.001 | 2.67 (1.55–4.60) | <.001 | 9.21 (4.53–18.73) | <.001 |
| >1 (mixed infection) | 5.29 (2.69–10.43) | <.001 | 2.52 (1.26–5.05) | .009 | 9.77 (4.39–21.73) | <.001 |
| Any, overall | 4.93 (3.79–6.42) | <.001 | 2.77 (2.20–3.48) | <.001 | 13.76 (10.22–18.54) | <.001 |
| Age among malarial patients, yb | ||||||
| <1 | 4.36 (1.80–10.56) | .001 | 3.96 (1.55–10.09) | .004 | 7.17 (2.60–19.79) | <.001 |
| 1 to <5 | 3.23 (1.92–5.43) | <.001 | 1.77 (.84–3.71) | .133 | 11.89 (6.52–21.66) | <.001 |
| 5 to <15 | 6.35 (3.24–12.46) | <.001 | 2.40 (1.14–5.04) | .021 | 5.98 (1.41–25.40) | .015 |
| ≥15 | 6.18 (4.28–8.92) | <.001 | 2.87 (2.19–3.77) | <.001 | 20.05 (13.57–29.62) | <.001 |
Abbreviations: CI, confidence interval; Hb, hemoglobin; OR, odds ratio.
Model presents risk with respect to the reference group of patients without severe anemia or thrombocytopenia (severe thrombocytopenia was defined as a platelet count of <50 000 platelets/μL, and anemia was defined as a Hb level of <5 g/dL). Adjusted for age group, sex, ethnicity, year, and recent malaria presentations in the past 2 months.
Model presents risk in patients with malaria, with respect to the reference group of patients without severe anemia or thrombocytopenia (severe thrombocytopenia was defined as a platelet count of <50 000 platelets/μL, and anemia was defined as a Hb level of <5 g/dL). Adjusted for species, sex, ethnicity, year, and recent malaria presentations in the past 2 months.