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. Author manuscript; available in PMC: 2015 Jan 24.
Published in final edited form as: Immunity. 2014 Jan 9;40(1):128–139. doi: 10.1016/j.immuni.2013.12.007

Figure 6. Role of Gpr109a expressed in hematopoietic and non-hematopoietic cells in regulation of colitis and colitis-associated colon cancer.

Figure 6

Reciprocal bone marrow chimeras of WT and Niacr1−/− mice were subjected to (AOM+DSS)-induced model of colitis-associated colon cancer.

(A) Weight loss and diarrhea after the first cycle of DSS (n≥4). *; significant difference between WT → Niacr1−/− and Niacr1−/− → Niacr1−/− group for weight loss (p<0.05) and diarrhea (p<0.02). **; Significant difference between WT → WT and Niacr1−/− → WT group for weight loss and diarrhea (p<0.02).

(B) Representative photographs of dissected colons from bone marrow chimeric mice.

(C) Tumor burden in bone marrow chimeras subjected to AOM+DSS induced colon cancer (n=4).

Error bars represent SD of mean. A representative of 2 independent experiments is shown.