Figure 1. IRI was performed and 24h after surgery EA-230 or vehicle treatment was given twice daily i.p. for four consecutive days.

The majority of vehicle treated mice died within four days after IRI (A). EA-230 treated mice receiving doses between 30 and 50mg/kg survived significantly better than vehicle treated mice (***p<0.005). Renal function measured by s-creatinine (B) showed the initial increase and normalized over time in the surviving mice of all groups. Renal blood flow (C, PAH clearance), glomerular filtration rate (D, inulin clearance) and urine output (E) were significantly higher in EA-230 treated mice (*p<0.05).