Figure 3. Isogenic transplantation (blue) revealed 90% survival for four weeks and normal renal function (B).

After allogenic kidney transplantation 90% of the vehicle treated mice died within seven days after nephrectomy of the contralateral native kidney of the recipients at day 4. In contrast 70% of EA-230 treated mice were still alive one week after ktx. 30% of the recipients treated with EA-230 achieved four week survival whereas all vehicle treated recipients died within the first two weeks. Renal function (B) deteriorated at day six in both allogenic ktx groups but was significantly better in EA-230 (green columns, ***p<0.005) than in vehicle treated allograft recipients (red columns).