Table 2. Selected KEGG gene pathways relating to cell communication and environmental information processing that were significantly enriched compared to HIV negative controls.

	Time	Term	KID	Adjusted P	OR	Expected count	Observed count
Control—ABC	6 m	ECM-receptor interaction	4512	0.036	1.80	16	25
		Focal adhesion	4510	0.036	1.40	41	53
		Tight junctions	4530	0.043	1.50	24	32
		Adherence Junction	4520	0.043	1.62	16	23
Control—ABC	18–24 m	Wnt signalling pathway	4310	0.045	1.49	27.1	36
		Adherence Junction	4520	0.045	1.65	16.2	23
		ECM-receptor interaction	4512	0.046	1.65	16.2	23
Control—AZT	6m	Cytokine-cytokine receptor interaction	4060	0.03	3.02	2.17	6
Control – AZT	18–24 m	Neuroactive ligand-receptor interaction	4080	<0.0001	2.78	26.1	54
		Cytokine-cytokine receptor interaction	4060	0.019	1.61	25	36
		ECM-receptor interaction	4512	0.034	1.78	11.5	18
Control—TDF	6 m	Cytokine-cytokine receptor interaction	4060	0.038	6.90	0.58	3
Control—TDF	18–24 m	Neuroactive ligand-receptor interaction	4080	<0.0001	2.67	25	51
		Cytokine-cytokine receptor interaction	4060	0.01	1.76	24	37
		ECM-receptor interaction	4512	0.021	2.03	11.1	19
		VEGF signalling pathway	4370	0.029	1.88	10.4	17
		WNT signalling pathway	4310	0.04	1.54	18.5	26

KID = Kegg identity; OR = odds ratio; Time = time after treatment