Table 3. Expression of genes controlling adherence junction in ABC treated group in comparison with controls at 6 months and 18–24 months after treatment.

Time on treatment	Upregulated	Down regulated	Adjusted p value
6 months	ACTN1, CSNK2A1, CTNNA1, CTNNB1, CTNND1, EGFR, EP300, FGFR1, INSR, IQGAP1, NLK, PTPN1, PTPRB, PTPRF, PTPRJ, PTPRM, RHOA, SMAD2, SORBS1,TCF7L1, TCF7L2, TGFBR1, TJP1,VCL	CLDN3, CLDN4, CLDN5, MAP3K3, PVRL1, RAC2, SNAI1, SNAI2,	– <0.01–<0.0001
18–24 months	ACTN1, CSNK2A1, CTNNA1, CTNNB1, EGFR, FGFR1, INSR, IQGAP1, MAP3K3, NKL, PTPN1, PTPRB, PTPRF, PTPRJ, PTPRM, RHOA, SMAD2, SORBS1, TCF7L2, TGFBR1, TJP1,VCL	CLDN3, CLDN4, CLDN5, MAP3K3, RAC2, SNAI1, SNAI2	<0.01–<0.0001

ACTN1 = actinin, alpha 1; CSNK = casein kinase; CLDN = claudin, CTNN = catenin (cadherin-associated protein); EGFR = epidermal growth factor receptor, EP300 = E1A binding protein p300; FGRF1 = fibroblast growth factor receptor 1; INSR = insulin receptor; IQGAP 1 = IQ motif containing GTPase activating protein 1; MAP3K7 = mitogen-activated protein kinase kinase kinase 7; MLLT4 = myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; NLK = nemo-like kinase; PTPRB, PTPRF, PTPRFJ, or PTPRFM = protein tyrosine phosphatase, receptor B, F, J, or M; PVRL 1 = poliovirus receptor-related 1 (herpesvirus mediator C); RAC2 = ras-related C3 botulinum toxin substrate; RHOA = ras homolog family member A; SMAD = SMAD family member; SNAI1 and SNAI2 = snail family zinc finger; SORBS1 = sorbin and SH3 domain containing 1 and 2; TCF7L1 and TCF7L2 = transcription factor 7-like; TGFBR = transforming growth factor 1 and 2, beta receptor; VCL = vinculin.