Skip to main content
. 2015 Jan 24;10(1):e0116227. doi: 10.1371/journal.pone.0116227

Figure 6. Inhibition of bone degradation and reduction of synovial inflammation in murine collagen-induced arthritis at different doses of PMP-311 (n = 15) and PMP-072 (n = 15) given by oral gavage from day 20 until day 34.

Figure 6

A, Semiquantitative scores for radiographic joint destruction of the knee joints. Joint destruction was significantly decreased in mice treated with PMP-311 2 mg/kg and 10 mg/kg compared to the control group. B, Semiquantitative scores for synovial inflammation, assessed by hematoxylin and eosin staining of the knee joints, showed a decrease of synovitis in mice treated with PMP-311 2 mg/kg and PMP-072 10 mg/kg. * P < 0.05 and ** P < 0.01 versus saline-treated mice.