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. 2015 Jan 24;10(1):e0116784. doi: 10.1371/journal.pone.0116784

Figure 2. Basal expression of miR-132/212 in detrusor smooth muscle is low yet induction following outlet obstruction occurs only in the detrusor layer.

Figure 2

Control mice and mice with smooth muscle-specific deletion of Dicer (KO) were used to examine the contribution of smooth muscle cells to miR-132 and miR-212 expression in the bladder (panels A through C). Panel A shows miR-212 expression in control and KO mice following separation of the detrusor and mucosa using micro-dissection. Panel B shows expression of miR-143, miR-145 and miR-1 in control and KO detrusor. Panel C shows the detrusor to mucosa expression ratio of miR-132 and miR-212 in control and KO bladders. Time-courses of miR-132/212 expression in detrusor following partial bladder outlet obstruction in the rat are shown in panel D. N = 4–10 throughout.