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. Author manuscript; available in PMC: 2016 Jan 30.
Published in final edited form as: Oncogene. 2014 Oct 20;34(31):4069–4077. doi: 10.1038/onc.2014.335

Figure 4. NR2E1 expression controls oncogene-induced senescence (OIS).

Figure 4

(a-b) NR2E1 expression prevents OIS. (a) IMR90 ER:RAS cells were infected with the indicated vectors. ER:RAS was induced by 200 nM 4OHT. 12 days after, cell growth was evaluated by crystal violet staining (a) and senescence induction by SA-β-Gal staining (b). (c) NR2E1 expression prevents the induction of INK4a and CDKN1a during OIS. IMR90 ER:RAS cells were infected with the indicated vectors, the expression of INK4a and CDKN1a was monitored by qRT-PCR.