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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Cell Signal. 2014 May 15;26(9):1985–1997. doi: 10.1016/j.cellsig.2014.05.007

Figure 9.

Figure 9

Schematic of 247R-induced serum- and agonist-independent cell proliferation and agonist-dependent cell hypertrophy in cardiomyoblasts. (A) 247R triggers constitutive, βarrestin1/Src/MMP-dependent EGFR transactivation, while tr247R cells exhibit βarrestin1/Src-dependent, but MMP-independent EGFR transactivation leading to ERK activation, cell cycle progression and cell proliferation. (B) Agonist stimulation of 247R or tr247R cells triggers Gq-dependent EGFR/STAT3 activation and hypertrophy.