Image 3.
Central nervous system vasculature loses LMO2 reactivity in older adults. A and B, The cortex of a 73-year-old adult shows LMO2− vasculature (A, ×400) with overlying LMO2+ subarachnoid vessels (B, ×400). C and D, The spinal cord from the 73-year-old adult shows LMO2− vessels (C, ×400) with adjacent nerve roots showing LMO2+ vasculature (D, ×400). E, The cortex of a 39-year-old adult shows LMO2+ vasculature (×400). F, Expression of LMO2 in brain tissue by immunoblotting. Actin serves as a loading control.