Table 4.

Proposed model of CETP effects on MCI/AD risk, baseline volumes and one-year atrophy in medial temporal lobe structures

	Protective for baseline volumes	Protective for one-year atrophy	Protective for risk of MCI/AD
APOE ε4 carriers	V allele (low CETP)	–	–
HC	A allele (low CETP)	–	–
MCI or AD	V allele (low CETP)		–
	A allele (low CETP)	A allele (low CETP)
APOE ε4 non-carriers	I allele (high CETP)	I allele (high CETP)	I allele (high CETP)
HC	I allele (high CETP)	–	–
MCI or AD	–	I allele (high CETP)	–

Alleles conferring low CETP and high HDL (V at I405V and A at C-629A) appear to be protective in APOE ε4 carriers, whereas alleles conferring high CETP and low HDL (I at I405V and C at C-629A) appear protective in non-carriers