Table 4.

Subgroup Analysis Among Women based on Menopausal Status

	Total	Pre-menopause (n=1435)	Post-menopause (n=1370)
Lumbar BMD (g/cm2)
Continuous*	0.011 (0.004,0.018)	0.012 (0.002,0.021)	0.009 (-0.004,0.022)
< 24 mEq/L	(referent group)	(referent group)	(referent group)
24-25 mEq/L	0.009 (-0.008,0.027)	0.008 (-0.020,0.036)	0.008 (-0.021,0.037)
25.1-26.9 mEq/L	0.017 (0.001,0.034)	0.021 (0.003,0.039)	0.011 (-0.015,0.038)
≥ 27 mEq/L	0.028 (0.009,0.048)	0.021 (-0.012,0.054)	0.033 (0.007,0.060)
P for trend	0.01	0.04	0.02
Total BMD (g/cm2)
Continuous*	0.006 (0.001,0.011)	0.005 (-0.001,0.011)	0.007 (-0.0003,0.014)
< 24 mEq/L	(referent group)	(referent group)	(referent group)
24-25 mEq/L	0.004 (-0.007,0.015)	0.004 (-0.011,0.020)	0.002 (-0.016,0.020)
25.1-26.9 mEq/L	0.006 (-0.003,0.015)	0.009 (-0.003,0.021)	0.003 (-0.014,0.019)
≥ 27 mEq/L	0.017 (-0.0003,0.035)	0.009 (-0.018, 0.037)	0.024 (0.006,0.042)
P for trend	0.05	0.2	0.02

Abbreviation: BMD, bone mineral density.

Note: n=2,805. Table shows association of serum bicarbonate with lumbar and total BMD Values are given as regression coefficient (95% confidence interval). Bold values indicate p<0.05. Models adjusted for age, race/ethnicity, menopause status, body mass index, poverty, education, activity level, smoking status, fasting length, diuretic and calcium carbonate use, diagnosis of diabetes mellitus, hypertension and cardiovascular disease, estimated glomerular filtration rate, albuminuria, serum albumin, calcium, phosphate and C-reactive protein.

^*Per 1-standard deviation higher serum bicarbonate (standard deviation = 2.2 mEq/L).