Table 4. Comparison of HTN Grading by Common Terminology Criteria for Adverse Events (CTCAE).
HTN Grade Definition | |||||
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CTCAE Version | 1 | 2 | 3 | 4 | 5 |
Version 2.0 (1999) | Asymptomatic; transient increase by >20 mm Hg (diastolic) or to >150/100 if previously WNL; not requiring treatment | Recurrent or persistent or symptomatic increase by >20 mm Hg (diastolic) or >150/100 if previously WNL, not requiring treatment | Requiring therapy or more intensive therapy than previously | Hypertensive crisis | Not applicable |
Version 3.0 (2003) | Asymptomatic; transient (<24 h) increase by >20 mm Hg (diastolic) or to >150/100 if previously WNL, intervention not indicated | Recurrent or persistent (≥ 24h) or symptomatic increase by >20 mm Hg (diastolic) or to >150/100 if previously WNL; monotherapy may be indicated | Requiring >1 drug or more intensive therapy than previously | Life-threatening consequences (eg, hypertensive crisis) | Death |
CTCAE indicates Common Terminology Criteria for Adverse Events; HTN, hypertension; WNL, Sngle within normal limits.