Table 4. Comparison of HTN Grading by Common Terminology Criteria for Adverse Events (CTCAE).

	HTN Grade Definition
CTCAE Version	1	2	3	4	5
Version 2.0 (1999)	Asymptomatic; transient increase by >20 mm Hg (diastolic) or to >150/100 if previously WNL; not requiring treatment	Recurrent or persistent or symptomatic increase by >20 mm Hg (diastolic) or >150/100 if previously WNL, not requiring treatment	Requiring therapy or more intensive therapy than previously	Hypertensive crisis	Not applicable
Version 3.0 (2003)	Asymptomatic; transient (<24 h) increase by >20 mm Hg (diastolic) or to >150/100 if previously WNL, intervention not indicated	Recurrent or persistent (≥ 24h) or symptomatic increase by >20 mm Hg (diastolic) or to >150/100 if previously WNL; monotherapy may be indicated	Requiring >1 drug or more intensive therapy than previously	Life-threatening consequences (eg, hypertensive crisis)	Death

CTCAE indicates Common Terminology Criteria for Adverse Events; HTN, hypertension; WNL, Sngle within normal limits.