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Pharmacological FAK inhibition promotes nuclear localization of FAK in RPMI-7951 human melanoma cells. GFP-FAK is stably expressed in RPMI-7951 cells. Cells were treated with PF-562,271 (1 μM) for 1–3 hr and cells were fixed. Images were collected with Nikon confocal microscope (A1R) and analyzed with NIS-Elements AR software. Nuclear localized FAK can be observed within 1 hr treatment of the FAK inhibitor. Green, FAK; Pseudo-colored Red, DAPI. Scale, 10 µm.
