Table 2.
The Top 50 Skin-enriched Genes.
| # | Gene Name | Description | Cellular Location* | Skin-Specific Score** | Expression in Skin (FPKM)*** | Max FPKM in Other Tissues**** |
|---|---|---|---|---|---|---|
| 1 | C1orf68 | chromosome 1 open reading frame 68 | IC | 3858.3 | 385.8 | 0.1 |
| 2 | LCE2B | late cornified envelope 2B | IC | 3716.6 | 386.5 | 0.1 |
| 3 | FLG2 | filaggrin family member 2 | IC | 2455.4 | 358.5 | 0.1 |
| 4 | LCE2C | late cornified envelope 2C | IC | 1874.1 | 187.4 | 0.1 |
| 5 | CDSN | corneodesmosin | SP | 1430.9 | 253.3 | 0.2 |
| 6 | LCE1A | late cornified envelope 1A | IC | 1275.7 | 164.6 | 0.1 |
| 7 | LCE6A | late cornified envelope 6A | IC | 1116 | 111.6 | 0 |
| 8 | KRT2 | keratin 2 | IC | 1060.1 | 1192.6 | 1.1 |
| 9 | LCE1F | late cornified envelope 1F | IC | 996.4 | 106.6 | 0.1 |
| 10 | LCE1B | late cornified envelope 1B | IC | 980.2 | 98 | 0 |
| 11 | LOR | loricrin | IC | 967 | 177.9 | 0.2 |
| 12 | LCE1C | late cornified envelope 1C | IC | 859.6 | 234.7 | 0.3 |
| 13 | CASP14 | caspase 14, apoptosis-related cysteine peptidase | IC | 758.3 | 260.1 | 0.3 |
| 14 | KRT77 | keratin 77 | IC | 636.6 | 222.2 | 0.3 |
| 15 | SERPINA12 | serpin peptidase inhibitor, clade A, member 12 | SP | 622.7 | 203.6 | 0.3 |
| 16 | LCE2D | late cornified envelope 2D | IC | 619.5 | 90.4 | 0.1 |
| 17 | LCE2A | late cornified envelope 2A | IC | 509.7 | 89.2 | 0.2 |
| 18 | KRT10 | keratin 10 | IC | 504.2 | 4147.2 | 8.2 |
| 19 | LCE1D | late cornified envelope 1D | IC | 474.3 | 55.5 | 0.1 |
| 20 | CCL27 | chemokine (C-C motif) ligand 27 | SP | 369.6 | 298.3 | 0.8 |
| 21 | LCE1E | late cornified envelope 1E | IC | 323 | 36.5 | 0.1 |
| 22 | IL37 | interleukin 37 | IC | 204.9 | 72.5 | 0.4 |
| 23 | LCE5A | late cornified envelope 5A | IC | 168.5 | 46 | 0.3 |
| 24 | KRT1 | keratin 1 | IC | 132.4 | 4698.1 | 35.5 |
| 25 | CLEC2A | C-type lectin domain family 2, member A | TM | 116.2 | 27 | 0.2 |
| 26 | TYR | tyrosinase (oculocutaneous albinism IA) | SP/TM | 115.7 | 28 | 0.2 |
| 27 | DCT | dopachrome tautomerase | SP/TM | 79.8 | 83.7 | 1.1 |
| 28 | MLANA | melan-A | TM | 70.5 | 35.4 | 0.5 |
| 29 | THEM5 | thioesterase superfamily member 5 | IC | 67.1 | 50.7 | 0.8 |
| 30 | PSORS1C2 | psoriasis susceptibility 1 candidate 2 | SP | 64.8 | 44.4 | 0.7 |
| 31 | ASPRV1 | aspartic peptidase, retroviral-like 1 | TM | 58.7 | 186 | 3.2 |
| 32 | WFDC5 | WAP four-disulfide core domain 5 | SP | 53.1 | 251.5 | 4.7 |
| 33 | SERPINB7 | serpin peptidase inhibitor, clade B, member 7 | IC | 50.8 | 112.7 | 2.2 |
| 34 | KRTDAP | keratinocyte differentiation-associated protein | SP | 50.3 | 2176.2 | 43.3 |
| 35 | SPRR2G | small proline-rich protein 2G | IC | 44.9 | 185.4 | 4.1 |
| 36 | FLG | filaggrin | IC | 43.8 | 320.8 | 7.3 |
| 37 | LCE4A | late cornified envelope 4A | IC | 42.9 | 4.3 | 0 |
| 38 | IGFL3 | IGF-like family member 3 | SP | 42.7 | 6.7 | 0.2 |
| 39 | BPIFC | BPI fold containing family C | SP | 37.1 | 48.2 | 1.3 |
| 40 | C6orf15 | chromosome 6 open reading frame 15 | SP | 32.5 | 3.3 | 0.1 |
| 41 | IL1F10 | interleukin 1 family, member 10 (theta) | IC | 30.6 | 3.1 | 0.1 |
| 42 | LIPK | lipase, family member K | SP | 28.8 | 10 | 0.3 |
| 43 | AADACL2 | arylacetamide deacetylase-like 2 | SP | 27.6 | 45.9 | 1.7 |
| 44 | POU2F3 | POU class 2 homeobox 3 | IC | 27.2 | 70.5 | 2.6 |
| 45 | ALOXE3 | arachidonate lipoxygenase 3 | SP | 26.8 | 40.4 | 1.5 |
| 46 | NLRP10 | NLR family, pyrin domain containing 10 | IC | 23.3 | 6.5 | 0.3 |
| 47 | RPTN | repetin | IC | 22.4 | 24 | 1.1 |
| 48 | NKPD1 | NTPase, KAP family P-loop domain containing 1 | TM | 20.6 | 8.2 | 0.4 |
| 49 | KPRP | keratinocyte proline-rich protein | IC | 19.7 | 160.6 | 8.1 |
| 50 | KRT14 | keratin 14 | IC | 19.6 | 4021.3 | 205.7 |
#, Sample number; FPKM, fragments per kilobase of exon model per million mapped reads. *IC=intracellular, SP=predicted signal peptide/secreted protein, TM=predicted transmembrane region/membrane bound protein. **The skin-specific score is the ratio of the mean FPKM value in skin and the maximal mean FPKM value for any other tissue type analyzed in this study. *** Mean expression level (FPKM) in skin, based on three samples. **** Highest expression level (FPKM) in non-skin tissues.