Table 4.
Combined genotype of GSTT1 and GSTP1 on colorectal cancer risk by tumor site and age in men.
|
GSTT1 / GSTP1 |
||||||
|
Present / (A/A) |
Present /with G + null / (A/A) |
Null /with G |
||||
| Cases/Controls | OR (95%CI)1 | Cases/Controls | OR (95%CI)1 | Cases/Controls | OR (95%CI)1 | |
| Total population2 | 132/157 | 1.00 | 205/191 | 1.42 (1.01-1.99) | 71/60 | 1.91 (1.21-3.02) |
| Tumor site | ||||||
| Colon | 64/157 | 1 | 88/191 | 1.16 (0.75-1.79) | 31/60 | 1.42 (0.79-2.55) |
| Rectum2 | 68/157 | 1.00 | 117/191 | 1.65 (1.09-2.50) | 40/60 | 2.20 (1.28-3.78) |
| Age at diagnosis | ||||||
| ≤60 yr2 | 57/73 | 1.00 | 96/89 | 1.73 (1.04-2.89) | 34/23 | 3.05 (1.51-6.12) |
| >60 yr | 75/84 | 1.00 | 109/102 | 1.25 (0.78-2.02) | 37/37 | 1.41 (0.75-2.64) |
1
Adjusted for age, physical activity, coffee, cigarette, alcohol, meat, vegetable/fruit and fish/shrimp;
2
Trend test P<0.01.