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. 2005 May 7;11(17):2616–2625. doi: 10.3748/wjg.v11.i17.2616

Figure 1.

Figure 1

Schematic drawing of pVHL domain composition. Epitope region for the monoclonal antibodies VHL06 and VHL40 used in immunohistochemistry is shown below the scheme[30]. Positions of primers (a = antisense, s = sense) used for the amplification of two overlapping RT-PCR products are indicated above the exon map. Involvement of HIF-α-binding β-domain and elongin C-binding α-domain of pVHL in the negative regulation of CA XII and CA IX is illustrated according to data described by Ivanov et al[6].