Table 2.
Contractile response of different agents to the endothelial-denuded aortic rings from sham and CBL rats.
| Vasopressor | Parameter | Sham | CBL |
| PEP | pEC50 | 6.41±0.1 | 6.53±0.8 |
| Rmax (g) (10-5 mol/L) | 3.29±0.37 | 1.99±0.21a | |
| AVP | pEC50 | 6.51±0.2 | 7.08±0.9 |
| Rmax (g) (10-5 mol/L) | 3.45±0.28 | 2.31±0.49a | |
| U-46619 | pEC50 | 7.43±0.13 | 7.81±0.26 |
| Rmax (g) (10-6 mol/L) | 3.18±0.27 | 3.19±0.17 | |
| NaF/AlCl3 | pEC50 | 0.83±0.43 | 1.01±0.01 |
| Rmax (g) (1 mol/L) | 3.68±0.13 | 3.42±0.25 | |
| PdBU | pEC50 | 7.05±0.4 | 7.05±0.7 |
| Rmax (g) (10-6 mol/L) | 3.87±0.14 | 3.92±0.22 |
Values are mean±SE; sham: sham-operated rats; CBL: common bile duct-ligation rats, PEP: phenylephrine, n = 10, in each group with different agonist stimulation,
a
P<0.05 vs sham rats.