Table 1.
The 27 predicted cooperative TF pairs
| Ranking | TF1 | TF2 | Consistent with existing methods' predictions | Having PPIs? | Co-annotated MIPS functional categories |
|---|---|---|---|---|---|
| 1 | Reb1 | YDR026C | [3] | -- | -- |
| 2 | Fkh2 | Fkh1 | [1],[2],[3],[4],[7],[8],[38] | Y | mitotic cell cycle and cell cycle control; budding, cell polarity and filament formation |
| 3 | Tye7 | Cbf1 | [3] | Y | metabolism |
| 4 | Dig1 | Ste12 | [3],[7],[20] | Y | protein folding; pheromone response, mating-type determination, sex-specific proteins; budding, cell polarity and filament formation |
| 5 | Pdr3 | Pdr1 | --- | Y | DNA binding; chemical agent resistance; detoxification |
| 6 | Swi6 | Mbp1 | [2],[3],[4],[5],[7],[20],[38] | Y | DNA synthesis and replication; mitotic cell cycle and cell cycle control; protein with binding function or co-factor requirement (structural or catalytic) |
| 7 | Swi6 | Swi4 | [2],[3],[4],[5],[7],[9],[20],[38] | Y | G1/S transition of mitotic cell cycle |
| 8 | Dal80 | Gln3 | --- | Y | regulation of nitrogen metabolism |
| 9 | Gln3 | Gat1 | [3] | Y | regulation of nitrogen metabolism |
| 10 | Dal80 | Gat1 | --- | -- | regulation of nitrogen metabolism |
| 11 | Pho4 | Cbf1 | --- | Y | metabolism; DNA binding |
| 12 | Pho4 | Tye7 | --- | -- | metabolism |
| 13 | Hap3 | Hap2 | [20] | Y | regulation of C-compound and carbohydrate metabolism |
| 14 | Gal80 | Gal4 | --- | Y | regulation of C-compound and carbohydrate metabolism |
| 15 | Met31 | Met32 | [3] | Y | metabolism of methionine; metabolism of cysteine; regulation of amino acid metabolism; regulation of nitrogen, sulfur and selenium metabolism; DNA binding |
| 16 | Msn4 | Msn2 | [3] | Y | DNA binding; stress response |
| 17 | Rap1 | Fhl1 | [3],[8],[20] | Y | --- |
| 18 | Tec1 | Ste12 | [3] | Y | budding, cell polarity and filament formation |
| 19 | Swi6 | Stb1 | [3],[7] | Y | G1/S transition of mitotic cell cycle |
| 20 | Hap2 | Hap5 | [8] | Y | regulation of C-compound and carbohydrate metabolism |
| 21 | Nrg1 | Nrg2 | --- | Y | protein with binding function or co-factor requirement (structural or catalytic); budding, cell polarity and filament formation |
| 22 | Hap3 | Hap5 | [8],[20] | Y | regulation of C-compound and carbohydrate metabolism |
| 23 | Swi4 | Stb1 | [3],[4],[7] | Y | G1/S transition of mitotic cell cycle |
| 24 | Swi5 | Ace2 | [2],[3],[4],[7],[9] | Y | G1 phase of mitotic cell cycle |
| 25 | Sok2 | Phd1 | [3] | Y | budding, cell polarity and filament formation |
| 26 | Hap5 | Hap4 | --- | Y | regulation of C-compound and carbohydrate metabolism |
| 27 | Mbp1 | Swi4 | [1],[2],[3],[6],[7],[9] | Y | mitotic cell cycle and cell cycle control |