Table 3. Stratification analysis of AhR genotype and CAD risk.
| CAD group | Control group | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype n(%) | Allele n(%) | Genotype n(%) | Allele n(%) | P value | |||||||||||
| Characteristics | GG | GA | AA | G | A | GG | GA | AA | G | A | Pg | Pg* | Pa | Pa* | AOR (95%CI) |
| Age | |||||||||||||||
| <65 years | 203(46.8) | 186(42.8) | 45(10.4) | 592(68.2) | 276(31.8) | 181(38.6) | 226(18.2) | 62(13.2) | 588(62.7) | 350(37.3) | 0.014 | 0.014 | 0.014 | 0.028 | 1.28(1.05–1.55) |
| ≥65 years | 212(42.0) | 235(46.5) | 58(11.5) | 659(65.2) | 351(34.8) | 153(38.3) | 197(49.4) | 49(12.3) | 503(63.0) | 295(37.0) | 0.319 | 0.319 | 0.329 | 0.658 | 1.10(0.91–1.34) |
| Gender | |||||||||||||||
| Male | 284(43.2) | 304(46.3) | 69(10.5) | 872(66.4) | 442(33.6) | 210(37.7) | 273(49.0) | 74(13.3) | 693(62.2) | 421(37.8) | 0.030 | 0.030 | 0.033 | 0.033 | 1.20(1.02–1.42) |
| Female | 131(46.4) | 117(41.5) | 34(12.1) | 379(67.2) | 185(32.8) | 124(39.9) | 150(48.2) | 37(11.9) | 398(64.0) | 224(36.0) | 0.246 | 0.492 | 0.245 | 0.245 | 1.15(0.91–1.47) |
| Smoking | |||||||||||||||
| Yes | 139(43.8) | 146(46.1) | 32(10.1) | 424(66.9) | 210(33.1) | 40(33.3) | 61(50.8) | 19(15.8) | 141(58.8) | 99(41.2) | 0.022 | 0.022 | 0.025 | 0.050 | 1.42(1.04–1.92) |
| No | 276(44.4) | 275(44.2) | 71(11.4) | 827(66.5) | 417(33.5) | 294(39.3) | 362(48.4) | 92(12.3) | 950(63.5) | 546(36.5) | 0.101 | 0.101 | 0.104 | 0.208 | 1.14(0.97–1.34) |
| Hypertension | |||||||||||||||
| Yes | 186(45.8) | 175(43.1) | 45(11.1) | 547(67.4) | 265(32.6) | 62(44.9) | 62(44.9) | 14(10.1) | 186(67.4) | 90(32.6) | 0.993 | 1.986 | 0.993 | 1.986 | 0.99(0.75–1.33) |
| No | 229(43.0) | 246(46.2) | 58(10.8) | 704(66.0) | 362(34.0) | 272(37.3) | 361(49.4) | 97(13.3) | 905(62.0) | 555(38.0) | 0.033 | 0.033 | 0.104 | 0.208 | 1.19(1.10–1.41) |
| Diabetes | |||||||||||||||
| Yes | 114(41.0) | 134(48.2) | 30(10.8) | 362(65.1) | 194(34.9) | 28(37.3) | 38(50.7) | 9(12.0) | 94(62.7) | 56(37.3) | 0.567 | 0.567 | 0.579 | 0.579 | 1.11(0.76–1.62) |
| No | 301(45.5) | 287(43.4) | 73(11.0) | 889(67.2) | 433(32.8) | 306(38.6) | 385(48.5) | 102(12.9) | 997(62.9) | 589(37.1) | 0.013 | 0.013 | 0.014 | 0.014 | 1.21(1.04–1.41) |
| Hyperlipidemia | |||||||||||||||
| Yes | 192(57.3) | 93(27.8) | 50(14.9) | 477(71.2) | 193(28.8) | 74(36.6) | 95(47.0) | 33(16.3) | 243(60.1) | 161(39.9) | 0.001 | 0.002 | <0.001 | <0.001 | 1.64(1.26–2.12) |
| No | 223(44.2) | 228(45.2) | 53(10.5) | 674(66.9) | 334(33.1) | 260(39.0) | 328(49.2) | 78(11.7) | 848(63.7) | 484(36.3) | 0.100 | 0.100 | 0.108 | 0.216 | 1.15(0.97–1.37) |
Abbreviations: CAD, coronary arterial disease; AOR: adjusted odds ratio; CI: confidence interval. Pg: P value of difference in genotypes between case and control groups. Pa: P value of difference in alleles between case and control groups.
*False discovery rate-adjusted P value for multiple hypotheses test using BH method.