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. 2015 Jan 26;5:8032. doi: 10.1038/srep08032

Figure 8. Sensitivity of the hTRPM2 variant hTRPM2-(+Δ15) to intracellular ADPR in the presence or absence of intracellular free Ca2+.

Figure 8

(a) Average data of wild-type hTRPM2 and hTRPM2-(+Δ15) under stimulation with either intracellular ADPR (1.2 mM + ≤10 nM [Ca2+]i or 0.15 mM + 1 μM [Ca2+]i) or extracellular 10 mM H2O2. ***Indicates a significant difference (P = 0.001) from Student's t-test. n = 6–11. Error bars are s.e. (b)–(d), Representative whole-cell patch clamp recordings on hTRPM2-(+Δ15) and wild-type hTRPM2 as indicated, either stimulated with 1.2 mM intracellular ADPR in the presence of ≤10 nM Ca2+ in the patch-pipette (b), (c) or with 0.15 mM ADPR in the presence of 1 μM Ca2+ in the patch pipette (d).