Table 2.
Total (n) | Early group (n = 107) | Others (n = 297) | Univariate analysis P |
Multivariate analysis |
||
RR (95%CI) | P | |||||
Age (yr) | 0.290 | |||||
< 60 | 175 | 51 | 124 | |||
≥ 60 | 229 | 56 | 173 | |||
Sex | 0.933 | |||||
Male | 316 | 84 | 232 | |||
Female | 88 | 23 | 65 | |||
Indocyanine green retention rate at 15 min | 0.193 | |||||
< 10% | 110 | 24 | 86 | |||
≥ 10% | 294 | 83 | 211 | |||
Underlying liver disease | 0.225 | |||||
Other | 194 | 46 | 148 | |||
Cirrhosis | 210 | 61 | 149 | |||
Alpha-fetoprotein (ng/mL) | < 0.001 | < 0.001 | ||||
< 100 | 280 | 52 | 228 | 1 | ||
≥ 100 | 124 | 55 | 69 | 2.939 (1.788, 4.830) | ||
Number of tumors | < 0.001 | < 0.001 | ||||
Single | 306 | 63 | 243 | 1 | ||
Multiple | 98 | 44 | 54 | 2.633 (1.548, 4.445) | ||
Growth pattern | 0.002 | |||||
Expanding | 372 | 91 | 281 | |||
Infiltrating | 32 | 16 | 16 | |||
Capsule | 0.230 | |||||
Absent | 82 | 26 | 56 | |||
Present | 322 | 81 | 241 | |||
Serosal invasion | 0.006 | 0.031 | ||||
Negative | 358 | 87 | 271 | 1 | ||
Positive | 46 | 20 | 26 | 2.110 (1.069, 4.164) | ||
Microvascular invasion | < 0.001 | 0.012 | ||||
Absent | 312 | 64 | 248 | 1 | ||
Present | 92 | 43 | 49 | 2.001 (1.163, 3.441) | ||
Surgical margin | 0.081 | |||||
Negative | 374 | 95 | 279 | |||
Positive | 30 | 12 | 18 | |||
Tumor size (mm) | 0.010 | |||||
< 50 | 312 | 73 | 239 | |||
≥ 50 | 92 | 34 | 58 |
The results of the univariate and multivariate analyses of the clinicopathologic factors contributing to early recurrence after the initial hepatectomy for hepatocellular carcinoma.