Table 3.
Independent predictors of venous thromboembolism for all ulcerative colitis patients; those admitted emergently to hospital and were medically responsive or underwent emergent colectomy; and those who underwent an emergent or elective colectomy
| Full cohort VTE (n = 1020)Adjusted OR (95%CI) | Emergent and medically responsive cohort VTE (n = 690)1Adjusted OR (95%CI) | Emergent and elective cohort VTE (n = 637)1Adjusted OR (95%CI) | |
| Age, yr | |||
| 18-32 | 1.00 | 1.00 | 1.00 |
| 33-47 | 1.56 (0.68-3.56) | 2.44 (0.81-7.34) | 1.35 (0.56-3.27) |
| ≥ 48 | 1.63 (0.74-3.59) | 2.29 (0.79-6.66) | 1.65 (0.72-3.75) |
| Disease course | |||
| Medical responsive | 1.00 | 1.00 | Not applicable |
| Elective colectomy | 3.69 (1.30-10.44) | Not applicable | 1.00 |
| Emergent colectomy | 5.28 (1.93-14.45) | 4.62 (1.66-12.88) | 1.59 (0.82-3.07) |
| VTE prophylaxis2 | |||
| No | Not applicable | 1.00 | 1.00 |
| Yes | 2.24 (0.99-5.03) | 1.38 (0.32-6.00) | |
| In-hospital complication | |||
| No | 1.00 | 1.00 | 1.00 |
| Yes | 2.68 (1.42-5.05) | 2.80 (1.26-6.24) | 2.53 (1.32-4.85) |
| Year | 1.10 (1.01-1.20) | Not significant3 | Not significant3 |
One patient was excluded in each of these cases due to missing data.
VTE prophylaxis with anticoagulants (e.g., heparin) was assessed preoperatively/in-hospital for the emergent colectomy and medically responsive cohort, and postoperatively for the emergent and elective colectomy cohort. VTE prophylaxis was not modeled for the entire cohort.
P value was > 0.1 when fitted into the regression model using stepwise selection. The following variables were tested in the multivariate model, but were not independent predictors in any of the models: sex, disease duration, comorbidities, extra-intestinal manifestations, extent of disease, blood in stool and frequency of bowel movements. 5-ASA: Azathioprine, prednisone, and infliximab; VTE: Venous thromboembolism.