Table 1.
Samples used were from four different studies: [1] age-matched control sheep fed a normal diet (control); [2] sheep fed a metabolic acidosis (MA) diet for six months followed by the MA diet and twelve months of MA diet and treated by vehicle (MA1), raloxifene (RAL) or alendronate (ALN); [3] sheep fed an MA diet for eight months followed by six months of the MA diet combined with vehicle (MA2) or zoledronate (ZOL); [4] sheep subjected to ovariectomy and fed an MA diet for a year, followed by a year of the MA diet and vehicle (MA3 + OVX) or parathyroid hormone (PTH). Control, MA1, RAL and ALN were euthanized after 12 months, MA2 and ZOL at 14 months and MA3 + OVX and PTH at 24 months.
| Month |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | |
| Control | 6 | Normal diet | |||||||||||||||||||||||
| MA1 | 3 | MA diet | MA + vehicle | ||||||||||||||||||||||
| ALN | 2 | MA diet | MA + alendronate | ||||||||||||||||||||||
| RAL | 2 | MA diet | MA + raloxifene | ||||||||||||||||||||||
| MA2 | 6 | MA diet | MA + vehicle | ||||||||||||||||||||||
| ZOL | 6 | MA diet | MA + zoledronate | ||||||||||||||||||||||
| MA3 + OVX | 6 | MA diet + OVX | MA + OVX + vehicle | ||||||||||||||||||||||
| PTH | 6 | MA diet + OVX | MA + OVX + PTH | ||||||||||||||||||||||