Figure 5.

Graphical depiction of gene duplicates that are shared between the Gb⁻ paralogon and the remaining three globin-defined paralogons (Cygb, Mb, and Hb) in the human genome. There are seven 4:1 gene families that unite the Gb⁻ paralogon with the Cygb, Mb, and Hb paralogons, there are seven 3:1 gene families that unite the Gb⁻ paralogon with two of the three globin-defined paralogons, and there are four 2:1 gene families that unite the Gb⁻ paralogon with a single globin-defined paralogon. On each chromosome, annotated genes are depicted as colored bars. The ‘missing’ globin gene on the Gb⁻ paralogon is denoted by an ‘X’. The shared paralogs are depicted in colinear arrays for display purposes only, as there is substantial variation in gene order among the four paralogons. For clarity of presentation, genes that are not shared between the Gb⁻ paralogon and any of the three globin-defined paralogons are not shown. In the human genome, the Gb⁻ paralogon on chromosome 19 shares multiple gene duplicates with fragments of the Hb paralogon on chromosomes 16 and 7, and fragments of the Mb paralogon on Chromosomes 12 and 22. Members of the EPN1, LMTK3, and KCNJ14 gene families that map to the Hb paralogon have been secondarily translocated from chromosome 16. From Hoffmann et al. (2012a).