Table 4.
Summary of experimental results according to recipients’ groups.
| Groups | Recipients | Graft survival (days) |
Diagnosis | Immuno-histology at rejection |
Peripheral anti-nonGal Ab | Virology | ||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Humoral staining |
Cellular infiltrate |
Preformed at XT |
Elicited at rejection |
PERV: R/D centromeric ratio |
Intragraft BCMV |
Intragraft PCMV |
||||
| Control group | V9910C | 4 | AXHR & AXCR | IgM, C3c, C4d, C5b-9 | Monocytes/CD4+ | IgM/IgG CDC | IgM/IgG CDC | ND | ND | ND |
| V857I | 3 | Id. | Id. | Id. | Id. | Id. | ND | ND | ND | |
|
| ||||||||||
| Group #1 | V893AA | 15 | AXHR & AXCR | IgM, C3c, C4d, C5b-9 | Monocytes/CD4+ | IgM/IgG CDC | IgM/IgG CDC | Neg | Neg | |
| PA956E | 13 | Id. | Id. | Id. | Id. | Id | <1 | Neg | Neg | |
| V907J | 12 | Id. | Id. | Id. | Id. | IgM CDC | <1 | Neg | Neg | |
|
| ||||||||||
| Group #2 | PA997C | 9 | AXHR & AXCR | IgM, C3c, C4d, C5b-9 | Monocytes/CD4+ | IgM/IgG CDC | * | >1 (NS) | Neg | +/− |
| V9912B | 9 | Id. | Id. | Id. | Id. | IgM/IgG CDC | <1 | Neg | + | |
| 022VB | 11 | Id. | Id. | Id. | Id. | IgG CDC | <1 | Neg | + | |
|
| ||||||||||
| Group #3 | PA936G | 12 | AXHR & AXCR | IgM, C3c, C4d, C5b-9 | Monocytes/CD4+ | IgM/IgG CDC | IgM/IgG CDC | >1(NS) | Neg | ++ |
| PA936F | 14 | Id. | Id. | Id. | Id. | Id. | <1 | Neg | ++ | |
| K24E | 12 | Id. | Id. | Id. | Id. | * | <1 | Neg | +++ | |
| K921F | 14 | Id. | Id. | Id. | Id. | * | <1 | Neg | +++ | |
|
| ||||||||||
| Group #4 | K13F | 11 | AXHR & AXCR | IgM, C3c, C4d, C5b-9 | Monocytes/CD4+ | IgM/IgG CDC | * | <1 | Neg | Neg |
AHXR: Acute Humoral Xenogeneic Rejection, ACXR: Acute Cellular Xenogeneic Rejection, CDC: Complement Dependant Cytotoxicity
*
elicited anti-nonGal Ab level and CDC at rejection < preformed anti-nonGal Ab level and CDC at XT, Neg: negative, ND: not done, NS: non significatnt. R/D: recipient/donor, XT: xenotransplantation.