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. Author manuscript; available in PMC: 2015 Jan 26.
Published in final edited form as: FEBS J. 2010 Jun;277(12):2584–2597. doi: 10.1111/j.1742-464X.2010.07668.x

Fig. 4.

Fig. 4

The Hth domain inhibits a linked activation domain. HepG2 cells were cotransfected with the Gal-TATA luciferase reporter (A, B), or the Gal-SV40 reporter (C) and the indicated GBD-Meis2 fusions. The effects of increasing amounts of GBD or GBD fusions to TGIF and Meis2e were tested on the Gal-TATA luciferase (D) or Gal-TK-luciferase (E) reporters. F) the GBD-Meis2 fusion constructs are shown schematically. Hth: homothorax homology domain, hr1 and hr2: homology regions 1 and 2, HD: homeodomain. The activation domain from Drosophila TGIFa is indicated as dTA.