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. 2014 Dec 24;14:14. doi: 10.1186/s12899-014-0014-0

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© Ippolito et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Altered metabolic pathways and process networks in plasma of rats after heat stress. Biochemicals were grouped by KEGG super-pathway and sub-pathway. Pathways meeting significance thresholds were plotted by number of affected metabolites per total number identified in the plasma (at right). Significance thresholds were determined by ANOVA, by ratio of heat/control at T_c,Max, 24 or 48 hours. The 48 hour endpoint was further subdivided into injured or uninjured animals by cardiac histopathology.