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. 2014 Dec 24;14:14. doi: 10.1186/s12899-014-0014-0

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© Ippolito et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Mitochondrial dysfunction suggested by elevated TCA cycle intermediates and 2-hydroxybutyrate (AHB) at T _c,Max . (A) Fold-change from control in biochemicals implicated in the TCA cycle. (B) The TCA cycle, with red circles indicating biochemicals with significant deviation from control after heat stress. *p < 0.05 heat exposed versus control rat, two-way ANOVA with contrasts.