Table 4.
Multivariate analysis of overall survival.
| Variables | Overall survival | ||
|---|---|---|---|
| HR (95% CI) | P value | Prognostic impact | |
| All 67 patients | |||
| FLT3 ITD mutation (compared with wild type) | 2.798 (1.041–7.517) | 0.041 | Poor |
| DNMT3A mutation (compared with wild type) | |||
| Nonsynonymous variations | 1.229 (0.391–3.864) | 0.724 | NS* |
| Deleterious mutations | 2.285 (0.459–11.374) | 0.313 | NS* |
| R882 mutation | 2.285 (0.459–11.374) | 0.313 | NS* |
| Increasing age | 1.023 (0.991–1.055) | 0.157 | NS |
| Increrasing BM blasts | 1.018 (0.986–1.051) | 0.285 | NS |
| SCT performed (compared to not performed) | 0.118 (0.035–0.399) | 0.001 | Good |
Note: P values were adjusted with FLT3 ITD mutation status, age, BM blast percentage, and stem cell transplantation performance status (in all 67 patients*).
FLT3: fms-related tyrosine kinase 3; ITD: internal tandem duplications; DNMT3A: DNA methyltransferase 3A; R: arginine; BM: bone marrow; SCT: stem cell transplantation; HR: hazard ratio; CI: confidence interval; NS: not significant.