Table 3.

Candidate Genes Predisposing Variation in DID Alcohol Consumption.

Transcript Information			Male DID Phenotype Correlation		eQTL information		Gene Product Function
Gene Symbol	Gene Name	Physical Location: Chr (Mb)	Coefficient	Nominal p-value (FDR)	eQTL Location Chr (Mb)	LOD Score (p-value)
Trim62	tripartite motif-containing 62	4 (128.9)	−0.62	0.0001 (0.037)	4 (128.6)	7.5 (<0.0001)	RING finger E3 ubiquitin ligase (Huang et al. 2013)
Wrn	Werner syndrome homolog (human)	8 (33.3)	−0.59	0.0002 (0.037)	4 (124.9)	8.8 (<0.0001)	RecQ-type DNA helicase involved in DNA repair, replication, transcription; deficiency leads to premature age-associated pathologies (Werner Syndrome) (Turaga et al. 2009).
Gtf3c1 (TFIIIC)	general transcription factor III C 1	7 (125.6)	0.58	0.0003 (0.037)	7 (125.2)	7.1 (<0.0001)	Transcription factor that interacts with tDNAs (tRNA genes) that act as chromatin insulators. Plays a key role in genome organization allowing for changes in gene transcription (Van Bortle and Corces 2012).
Pld5	phospholipase D family, member 5	1 (176.0)	0.58	0.0004 (0.037)	1 (175.6)	20.7 (<0.0001)	Converts phosphatidylinositol 3, 4, 5- trisphosphate to inositol 3, 4, 5 trisphosphate and phosphatidic acid (Ching et al. 1999).
Arntl (Bmal1)	aryl hydrocarbon receptor nuclear translocator-like	7 (113.2)	−0.55	0.0007 (0.060)	7 (124.6)	3.8 (0.0260)	Transcription factor, core component of mammalian circadian rhythm system; regulates behavioral, physiological and chromatin modification rhythms (Hatanaka et al. 2010; Menet et al. 2014; Mieda and Sakurai 2011).

Candidate genes were identified based on significant correlation of transcript clusters with the male DID phenotype and eQTL overlap with DID phenotype QTL.