Table 1. Toxicity Grade of Lungs of the Mice Treated With Intratracheal Injection 5-Azacytidine.
Days | 4 | 7 | 14 | 28 |
---|---|---|---|---|
I.T. 5-Aza (90 mg/kg) | 0a | 2a | 0a | 0 |
I.T. 5-Aza (2.5 mg/kg × 3) | 0 | 0a | 0 | 0 |
I.T. Vehicle | 0a | 0a | 0a | 0 |
I.V. 5-Aza (90 mg/kg) | 0 | 0 | 0 | 0 |
No Treatment | 0 | 0a | 0 | 0 |
Histopathologic photographs are shown in Figure 4.
Abbreviations: 5-Aza = 5-azacytidine; I.T. = intratracheal injection