Table 1.
Cytokine profiles of splenocytes from mice inoculated with buffer control, AdEmpty control, AdSalp15, AdIsac, or pooled AdSalps at 48 h post stimulation with ConA. AdSalp15 levels were similar to that of the buffer control. AdIsac, however, demonstrated a large and statistically significant increase in IFN-γ, TNF-α, and IL-2 as compared to controls. A statistically significant increase in IFN-γ and TNF–α was observed in pooled AdSalps as compared to controls.
| Buffer | AdEmpty | AdSalp15 | AdIsac | Pooled AdSalps |
|
|---|---|---|---|---|---|
| IFN-γ (pg/mL) | 1289.6 | 1052.4 | 2121.3 | 3147.7** | 2958.7*** |
| TNF-α (pg/mL) | 59.4 | 95.80 | 175.7 | 493.5*** | 385.4* |
| IL-2 (pg/mL) | 172.6 | 196.1 | 67.1 | 635.5*** | 210.1 |
p = 0.0036.
p = 0.0003.
p < 0.0001.