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. Author manuscript; available in PMC: 2015 Jan 26.
Published in final edited form as: Eur J Neurosci. 2012 Jan;35(1):34–43. doi: 10.1111/j.1460-9568.2011.07944.x

Figure 1.

Figure 1

Expression of Trpm1 and Trpm3 mRNA. (A) Microarray data show that Trpm1 and Trpm3 are acutely regulated by light in the eye of mice lacking rods and cones (rd/rd cl). Trpm1 was significantly upregulated in response to light (**=F3,12 =13.4, P=0.00039, P=0.0054 with FDR correction), whereas Trpm3 was significantly downregulated (*=F3,12 =7.38, P= 0.0046, P=0.0079 with FDR correction). (B, C) Both Trpm1 and Trpm3 mRNA are detected in the retinal ganglion cell layer of wildtype mice, based upon PCR analysis of cDNA from isolated ganglion cell layer preparations. (B) Retinal section stained with 20% cresyl violet, following the isolation of a retinal ganglion cell layer preparation using laser capture microdissection (typically 30-40 cells/preparation). (C) Summary table showing the expression of Trpm1, Trpm3, Opn4 and β-actin in 12 ganglion cell layer preparations.