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. Author manuscript; available in PMC: 2015 Jul 7.
Published in final edited form as: Nat Commun. 2015 Jan 7;6:5717. doi: 10.1038/ncomms6717

Figure 6. Model of PSR-1-mediated clearance of apoptotic cells.

Figure 6

PS exposed on the surface of the apoptotic cell interacts with and induces oligomerization of PSR-1, which then transduces the “eat-me” signal through interacting with CED-5 and CED-12, leading to the activation of the CED-10 GTPase and membrane extension of the phagocyte to enclose and internalize the apoptotic cell. At least one unknown phagocyte receptor (?) acts in parallel to PSR-1 in this signaling pathway.