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. 2014 Feb 16;6(1):56–75. doi: 10.14336/AD.2014.0209

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Figure 2. — Pleiotropic effects of a multistep cellular senescence program on aging and cancer. Multiple mechanisms underlying the advancement of the cellular senescence program through temporally and spatially separable steps impose antagonistically pleiotropic effects on aging and cancer. For additional details, see text. Abbreviations: CXCR-2/IL-8RB, a receptor of the pro-inflammatory cytokine IL-8; IGFBP-7, an insulin-like growth factor binding protein type 7; IGFBP-7, PAI-1, a plasminogen activator inhibitor type 1; SASP, a senescence-associated secretory phenotype; SMS, senescence-messaging secretome.